Anti-Calcium Channel (α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit
SIGMA/C1603 - affinity isolated antibody
Synonym: Anti-CACH2; Anti-CACN2; Anti-CACNL1A1; Anti-CCHL1A1; Anti-CaV1.2; Anti-LQT8; Anti-TS; Anti-TS. LQT8
MDL Number: MFCD02095952
Product Type: Chemical
Chitinase specificity: Chitin is a polymer of β-(1-4)-N--acetyl-D-glucosamine units
Immunohistochemistry Anti-Cav1.2: Cat. No. C1603: Immunohistochemical staining of Mouse cerebellum with Anti-Cav1.2 antibody. A. Cav1.2 (red) appears in Purkinje cells (horizontal arrows) and is distributed diffusely in the molecular layer (Mol) including in Purkinje dendrites (vertical arrows). B. Staining of Purkinje nerve cells with Mouse anti-Calbindin 28K (green) demonstrates the location of dendrites in the molecular layer. C. Merged image of panels A and B.
Immunoblotting Anti-Cav1.2: Cat. No. C1603: Western blot analysis of Rat brain membranes. Lanes 1. Anti-Cav1.2 antibody, (1:200). 2. Anti-Cav1.2 antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| Quality Level | 100  |
| species reactivity | human, rat, mouse, rabbit |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable using Rat brain sections |
| western blot: 1:200 using Rat brain and rat heart membranes | |
| UniProt accession no. | Q13936  |
| Application: | Anti-Calcium Channel (α1C Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit has been used in: • SDS-PAGE • western blotting • coimmunoprecipitation |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Immunohistochemistry (1 paper) |
| Application: | Rabbit polyclonal anti-Calcium Channel α1C subunit antibody is used to tag class C L-type calcium channel subunit α1C for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as ELISA, immunoblotting, and immunoprecipitation. It is used as a probe to determine the presence and roles of calcium channel subunit α1C in class C L-type voltage-gated Ca2+ channel subunit complexes. |
| Biochem/physiol Actions: | Anti-Voltage-gated Calcium Channel α1C subunit recognizes the α1C subunit by immunoblotting in rat brain and rat heart membranes. Reactivity has been confirmed for rat, mouse, rabbit and human. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | L-type of Voltage-gated Ca2+ Channels (L-type VGCC) is a high voltage-activated channel that exerts spatial and temporal control over cellular calcium concentrations and modulates function such as neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression and neuronal survival. Calcium dependent processes are important in synaptic modification and thus alterations in calcium channel function may be important for both modifying synaptic plasticity and also in age-related neurodegenerative diseases. Calcium channel antagonists are used as antiarrhythmics and in the treatment of hypertension and may even be neuroprotective in Parkinson’s Disease. Calcium Channel α1C subunit is a pore-forming subunit that together with β subunits generates the necessary signal for membrane targeting of class C L-type calcium channels. |
| Immunogen: | synthetic peptide corresponding to amino acids 848 to 865 of rat α1C. |
| Physical form: | Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |