Complement component C1q from human serum
SIGMA/C1740 - ≥95% (SDS-PAGE)
Synonym: C1q from human serum
CAS Number: 80295-33-6
MDL Number: MFCD00130851
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C1740-.5MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C1740-1MG
| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| form | liquid |
| Quality Level | 200  |
| shipped in | dry ice |
| storage temp. | −70°C |
| technique(s) | activity assay: suitable |
| UniProt accession no. | P02745  |
| P02746 |
|
| P02747 |
| Application: | Complement component C1q is an important regulator factor for platelet activation. This has been a topic for research, as platelet-leukocyte aggregates play an important role in inflammatory conditions such as coronary heart disease. In particular, C1q has been shown to inhibit collagen induced aggregation and enhance production of reactive oxygen species (ROS). |
| Biochem/physiol Actions: | C1q deficiency, either because of rare homozygous genetic defect, or transcriptional/translati |
| General description: | C1q, together with C1r and C1s, in the ratio of 1:2:2, form the C1 complex which is the first component of the classical complement pathway. C1q is composed of 18 polypeptide chains (six A, six B, six C) (MW 460 kDa). All contain an 81-aa collagen-like region composed of (Gly-Xaa-Yaa) repeating sequences close to the N-terminus. Three chains (A1B1C1) form a triple helix with the C-terminus forming the globular heads which may be structurally and functionally distinct domains. |
| Physical form: | Supplied as a solution in 10 mM HEPES, 300 mM NaCl, pH 7.2 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |