Capsazepine

SIGMA/C191 - ≥98% (HPLC), solid

Synonym: N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide

CAS Number: 138977-28-3
Empirical Formula (Hill Notation): C₁₉H₂₁ClN₂O₂S
Molecular Weight: 376.90
MDL Number: MFCD00153778
Linear Formula: C₁₉H₂₁ClN₂O₂S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C191-5MG	5 mg	$265.00 1/EA	Add To Favorites
45-C191-25MG	25 mg	$930.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	off-white
form	solid
InChI	1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
InChI key	DRCMAZOSEIMCHM-UHFFFAOYSA-N
Quality Level	100
SMILES string	Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc3ccc(Cl)cc3
solubility	DMSO: >10 mg/mL, clear
storage temp.	2-8°C

Application:	Capsazepine has been used as a transient receptor potential vanilloid-1 (TRPV1) antagonist: • to study its effect on capsaicin induced extracellular signal-regulated kinase (ERK) phosphorylation • to study the role of TRPV1 in central terminals on nociception in rats • for functional characterization of the TRPV1 in bull spermatozoa
Biochem/physiol Actions:	Capsazepine is a synthetic analog of capsaicin and a transient receptor potential vanilloid-1 (TRPV1) antagonist. It exhibits anti-proliferative and anti-cancer effects in various cancer types including oral squamous cell carcinoma, non-small cell lung cancer (NSCLC), breast cancer, and prostate cancer cell lines (HSC-3, H460, MDA-231, and PC-3 respectively). Capsazepine recovers impaired lung mechanics during endotoxemia and it may be a potential therapeutic target for acute lung injury (ALI).
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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