8-(3-Chlorostyryl)caffeine

SIGMA/C197 - ≥98% (HPLC), solid

Synonym: 1,3,7-Trimethyl-8-(3-chlorostyryl)xanthine; CSC

CAS Number: 147700-11-6
Empirical Formula (Hill Notation): C₁₆H₁₅ClN₄O₂
Molecular Weight: 330.77
MDL Number: MFCD00210188
Linear Formula: C₁₆H₁₅ClN₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C197-25MG	25 mg	$339.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	solid
InChI	1S/C16H15ClN4O2/c1-19-12(8-7-10-5-4-6-11(17)9-10)18-13-14(19)20(2)16(23)21(3)15(13)22/h4-9H,1-3H3/b8-7+
InChI key	MHYRUZOJQQLLQS-BQYQJAHWSA-N
Quality Level	100
SMILES string	[H]C(=C([H])c1nc2C(=O)N(C)C(=O)N(C)c2n1C)c3cccc(Cl)c3
solubility	DMSO: >5 mg/mL
storage temp.	−20°C

Application:	8-(3-Chlorostyryl)caffeine has been used as an adenosine A_2A receptor antagonist: • to study its effects on levodopa (L-DOPA)-induced dopamine (DA) release in rat striatum • to study its effect on the nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) activity in macrophages • to determine its effects on human umbilical vein endothelial cells (HUVECs)
Biochem/physiol Actions:	8-(3-Chlorostyryl)caffeine is a selective adenosine A_2A receptor antagonist and monoamine oxidase B (MAO B) inhibitor.
Disclaimer:	Photosensitive, store in the dark
Features and Benefits:	This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	25, 100 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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