α-Cyano-4-hydroxycinnamic acid
SIGMA/C2020 - ≥98% (TLC), powder
Synonym: α-CCA; α-CHCA; α-Cyano; 4-HCCA; ACCA
CAS Number: 28166-41-8
Empirical Formula (Hill Notation): C10H7NO3
Molecular Weight: 189.17
EC Number: 248-879-1
MDL Number: MFCD00004204
Linear Formula: HOC6H4CH=C(CN)CO2H
Product Type: Chemical
ATR-IR Spectra for α-CCA.
| assay | ≥98% (TLC) |
| color | yellow |
| form | powder |
| InChI | 1S/C10H7NO3/c11-6-8(10(13 |
| InChI key | AFVLVVWMAFSXCK-VMPITWQZSA |
| mp | 245-250 °C (lit.) |
| Quality Level | 300  |
| SMILES string | OC(=O)C(=Cc1ccc(O)cc1)C |
| solubility | H2O: slightly soluble |
| methanol: water: soluble | |
| polar organic solvents: soluble | |
| storage temp. | 2-8°C |
| Application: | α-Cyano-4-hydroxycinnamic acid has been used to block monocarboxylate transporters. |
| Application: | α-Cyano-4-hydroxycinnamic acid is a useful hydrophobic matrix solution for matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Antibiotics, peptide nucleic acids (a new class of DNA mimics), and proteins with masses as high as 66,000 Da have been successfully analyzed by using this as a matrix solution. |
| Biochem/physiol Actions: | α-Cyano-4-hydroxycinnamic acid acts as a specific inhibitor of monocarboxylic acid transport, including lactate and pyruvate transport. It is also reported to block β-cell apical anion exchange (IC50 of 2.4 mM). |
| Packaging: | 10, 25 g in poly bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H317 - H319 - H335 |
| Precautionary statements | P280 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (TLC) |
| mp | 245-250 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352106 |