DMT-2′O-TBDMS-rC(ac) Phosphoramidite

SIGMA/C213050 - configured for (ÄKTA^® and OligoPilot^®)

Synonym: N-acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-cytidine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

CAS Number: 121058-88-6
Empirical Formula (Hill Notation): C₄₇H₆₄N₅O₉PSi
Molecular Weight: 902.10
MDL Number: MFCD09842111
Linear Formula: C₄₇H₆₄N₅O₉PSi
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C213050-2G	2 g	$207.00 1/EA	Add To Favorites
45-C213050-5G	5 g	$451.00 1/EA	Add To Favorites
45-C213050-10G	10 g	$816.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

λ	conforms (UV/VIS Identity)
assay	≥99% (³¹P-NMR)
	≥99.0% (reversed phase HPLC)
biological source	non-animal source (no BSE/TSE risk)
color	white to off-white
compatibility	configured for (ÄKTA^® and OligoPilot^®)
form	powder
impurities	≤0.3% water content (Karl Fischer)
	≤0.5% P(III) Impurities 100-169ppm (³¹P-NMR)
	≤0.5% single Impurity (reversed phase HPLC)
	≤3% residual Solvent content
InChI	1S/C47H64N5O9PSi/c1-32(2)52(33(3)4)62(58-30-16-28-48)60-42-40(59-44(43(42)61-63(11,12)46(6,7)8)51-29-27-41(49-34(5)53)50-45(51)54)31-57-47(35-17-14-13-15-18-35,36-19-23-38(55-9)24-20-36)37-21-25-39(56-10)26-22-37/h13-15,17-27,29,32-33,40,42-44H,16,30-31H2,1-12H3,(H,49,50,53,54)/t40-,42-,43-,44-,62?/m1/s1
InChI key	QKWKXYVKGFKODW-YOEDQOPESA-N
nucleoside profile	base: cytidine base protecting group: acetyl 2' protecting group: TBDMS 5' protecting group: DMT deprotection: fast/standard
product line	Proligo Reagents
Quality Level	300
SMILES string	COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(C)=O)=NC3=O)(c4ccccc4)c5ccc(OC)cc5
storage temp.	−20°C
suitability	conforms to structure for H-NMR
	conforms to structure for LC-MS
technique(s)	oligo synthesis: suitable

Features and Benefits:	• Industry standard 2′O-TBDMS protective group • Consistent lot-to-lot purity and performance • Compatible with deprotection methods based on methylamine or AMA • Standard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as an activator; best results are obtained with Activator 42 • Capping with standard acetic anhydride capping reagent rather than with fast Deprotection Cap A • Manufactured under a certified ISO 9001 quality system
General description:	DMT-2′O-TBDMS-rC(ac) Phosphoramidite belongs to the 2′O-TBDMS RNA Phosphoramidites.
Legal Information:	ÄKTA is a registered trademark of Cytiva
Legal Information:	OligoPilot is a registered trademark of Cytiva

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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