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(Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide

SIGMA/C2175 - ≥97% (HPLC), powder

Synonym: CCK-8; Cholecystokinin octapeptide; Pancreozymin C-terminal octapeptide; Sincalide

CAS Number: 25126-32-3
Empirical Formula (Hill Notation): C49H62N10O16S3
Molecular Weight: 1143.27
EC Number: 246-639-0
MDL Number: MFCD00079849
Linear Formula: C49H62N10O16S3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C2175-250UG 250 µg
 $278.00
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45-C2175-.5MG 0.5 mg
 $459.00
1/EA		 Add To Favorites
45-C2175-1MG 1 mg
 $656.00
1/EA		 Add To Favorites
45-C2175-5MG 5 mg
 $2710.00
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assay ≥97% (HPLC)
form powder
InChI 1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35?,36-,37-,38-,39-/m0/s1
InChI key IZTQOLKUZKXIRV-IVVJSLGPSA-N
Quality Level 200 
SMILES string CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NC(CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
storage temp. −20°C
UniProt accession no. P06307 
  P30551 
  P30553 
Amino Acid Sequence: Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2
Application: (Tyr[SO3H]27)Cholecystokinin fragment 26-33 amide has been used to test its effects:
• to study its effects on β5i/LMP7 immunoproteasome subunit in pancreatitis
• on gastric emptying,food intake and c-Fos immunoreactivity in small litter (SL) and normal litter (NL) rats
• on the intestine and gallbladder motility in fish Ballan Wrasse
Biochem/physiol Actions: (Tyr[SO3H]27)Cholecystokinin fragment 26-33 amide activates the cholecystokinin type B receptor and may mediate the blockage of opioid analgesia. It elicits anti-inflammatory effects. It mediates the inhibition on cytokine release, lymphocytes, and macrophages.
Biochem/physiol Actions: Neurotransmitter; predominant form of CCK in CNS and gastrointestinal tract; may play a role in satiety.
General description: (Tyr[SO3H]27)Cholecystokinin fragment 26-33 amide is a sulfated cholecystokinin(CCK) octapeptide derived from the proCCK. It is present in plasma and endocrine cells.
Other Notes: C-Terminal octapeptide of cholecystokinin
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. −20°C
UNSPSC 51111800

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