Cerulenin
SIGMA/C2389 - ≥98% (HPLC), from Cephalosporium caerulens
Synonym: Helicocerin; (2R,3S,E,E)
CAS Number: 17397-89-6
Empirical Formula (Hill Notation): C12H17NO3
Molecular Weight: 223.27
EC Number: 241-424-8
MDL Number: MFCD00083595
Linear Formula: C12H17NO3
Product Type: Chemical
| antibiotic activity spectrum | fungi |
| assay | ≥98% (HPLC) |
| biological source | Cephalosporium caerulens |
| form | powder |
| InChI | 1S/C13H18O3/c1-3-4-5-6-7- |
| InChI key | PTNNGEBMCNMENY-JIVMHGEESA |
| mode of action | enzyme | inhibits |
| mp | 93 °C |
| Quality Level | 200  |
| SMILES string | C/C=C/C/C=C/CCC([C@@H]1[C |
| solubility | acetone: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to yellow |
| storage temp. | −20°C |
| Application: | Cerulenin has been used: • as a fatty acid synthase inhibitor to study its effects on aldosterone-induced trained immunity • as a blocker of fatty acid synthase to study its effects on the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) • as a supplement in yeast extract–peptone–dextrose/ |
| General description: | Cerulenin, an inhibitor of de novo phospholipid synthesis triggers apoptosis in various wild type p53 and mutant p53 tumor cell lines. This fungal antibiotic also blocks the condensing enzyme involved in fatty acid and polyketide biosynthesis. |
| Packaging: | 5, 10, 50 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| mp | 93 °C |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |