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CNQX disodium salt hydrate

SIGMA/C239 - ≥98% (HPLC), solid

Synonym: 6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate

CAS Number: 115066-14-3 (free base)
Empirical Formula (Hill Notation): C9H2N4Na2O4 · xH2O
Molecular Weight: 276.12 (anhydrous basis)
MDL Number: MFCD09953908
Linear Formula: C9H2N4Na2O4 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C239-5MG 5 mg
 $168.00
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45-C239-25MG 25 mg
 $503.00
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45-C239-100MG 100 mg
 $1170.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C239-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C239-25MG

 

assay ≥98% (HPLC)
color orange to red
form solid
InChI 1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2
InChI key LCDWHGXMFAZHEO-UHFFFAOYSA-L
Quality Level 100 
SMILES string O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O
solubility H2O: >2 mg/mL (warmed)
storage condition protect from light
Application: CNQX disodium salt hydrate has been used as:
• as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
• as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
• as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)
Biochem/physiol Actions: CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). It displays micromolar affinity towards AMPA/kainate receptor.
Biochem/physiol Actions: Potent, competitive AMPA/kainate receptor antagonist.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25, 100 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352200

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