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Corticosterone

SIGMA/C2505 - ≥92%

Synonym: 11β,21-Dihydroxy-4-pregnene-3,20-dione; 11β,21-Dihydroxyprogesterone; 4-Pregnene-11β,21-diol-3,20-dione; Kendall’s Compound B; Reichstein’s Substance H

CAS Number: 50-22-6
Empirical Formula (Hill Notation): C21H30O4
Molecular Weight: 346.46
EC Number: 200-019-6
MDL Number: MFCD00037715
Linear Formula: C21H30O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C2505-500MG 500 mg
 $103.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C2505-500MG

 

assay ≥92%
biological source synthetic (organic)
form powder
InChI 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChI key OMFXVFTZEKFJBZ-HJTSIMOOSA-N
mp 179-183 °C (lit.)
Quality Level 200 
shipped in ambient
SMILES string C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
solubility chloroform: 50 mg/mL, clear, colorless to faintly yellow
storage temp. room temp
Application: Corticosterone has been used:
• in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice
• as a stress inducing hormone in pregnant mice
• to test its effect on depression-related behaviors in mice
Biochem/physiol Actions: Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.
Biochem/physiol Actions: Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands. However, it may also be synthesized in non-adrenal tissues including leydig cells of testes and in murine thymus. Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress. It is produced by HPA activation in response to stress in myeloid cells. Elevated levels of corticosterone is observed in Huntington′s disease (HD).
Packaging: 500 mg in glass bottle
Hazard Codes Xi
Risk Statements 43
Safety Statements 36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥92%
mp 179-183 °C (lit.)
Storage Temp. room temp
UNSPSC 51111800

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