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Carboplatin

SIGMA/C2538

Synonym: cis-Diammine(1,1-cyclobutanedicarboxylato) platinum

CAS Number: 41575-94-4
Empirical Formula (Hill Notation): C6H12N2O4Pt
Molecular Weight: 371.25
EC Number: 255-446-0
MDL Number: MFCD00070464
Linear Formula: [C4H6(CO2)2]Pt(NH3)2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C2538-100MG 100 mg
 $237.00
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45-C2538-250MG 250 mg
 $479.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C2538-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C2538-250MG

 

antibiotic activity spectrum neoplastics
form powder
InChI 1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2
InChI key OLESAACUTLOWQZ-UHFFFAOYSA-L
originator Bristol-Myers Squibb
Quality Level 100 
SMILES string N.N.O=C1O[Pt]OC(=O)C12CCC2
Application: Carboplatin has been used:
• in chemotherapy-induced thrombocytopenia mouse model and treatment
• to induce cell death in a large subset of colorectal cancer cells
• in the evaluation of cell proliferation and chemosensitivity
• as a positive control for suppressed cell growth
Biochem/physiol Actions: Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by Bristol-Myers Squibb . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: Carboplatin is used to treat testicular, ovarian and breast cancer.
Packaging: 100, 250 mg in glass bottle
UNSPSC 12352200

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