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Chromanol 293B

SIGMA/C2615 - ≥98% (HPLC), powder

Synonym: trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide

CAS Number: 163163-23-3
Empirical Formula (Hill Notation): C15H20N2O4S
Molecular Weight: 324.40
MDL Number: MFCD06798368
Linear Formula: C15H20N2O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C2615-10MG 10 mg
 $224.00
1/EA		 Add To Favorites
45-C2615-50MG 50 mg
 $929.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form powder
InChI 1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1
InChI key HVSJHHXUORMCGK-UONOGXRCSA-N
Quality Level 100 
SMILES string CCS(=O)(=O)N(C)[C@@H]1[C@@H](O)C(C)(C)Oc2ccc(cc12)C#N
solubility DMSO: 18 mg/mL
storage temp. −20°C
Application: Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes.
Biochem/physiol Actions: Blocker of the slow delayed rectifier K+ current via KCNQ1 channels
Features and Benefits: This compound is featured on the Potassium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents. Chromanol 293B improves glucose-stimulated insulin secretion (GSIS) in pancreas by modulating potassium voltage-gated channel (KCNQ1).
Packaging: 10, 50 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302 - H312 - H332
Precautionary statements P280
Hazard Codes Xn
Risk Statements 20/21/22
Safety Statements 7/9-36/37
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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