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Cytochalasin D

SIGMA/C2618 - Ready Made Solution, from Zygosporium mansonii, 5 mg/mL in DMSO

Synonym: Lygosporin A; Zygosporin A

CAS Number: 22144-77-0
Empirical Formula (Hill Notation): C30H37NO6
Molecular Weight: 507.62
MDL Number: MFCD00077706
Linear Formula: C30H37NO6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C2618-200UL 200 µL
 $223.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum fungi
biological source Zygosporium mansonii
concentration 5 mg/mL in DMSO
form ready-to-use solution
InChI 1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
InChI key SDZRWUKZFQQKKV-JHADDHBZSA-N
mode of action enzyme | interferes
Quality Level 300 
shipped in wet ice
SMILES string [H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3C=CC[C@H](C)C(=O)[C@](C)(O)C=C[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4
storage temp. −20°C
Application: Cytochalasin D are isomeric metabolites of Metarrhizium anisopliae. Cytochalasin D possesses antibiotic and antitumor activity. It also impairs maintenance of long term potentiation (LTP) of actin filaments. It is implicated in promoting conditions favorable for depolymerizing actin.
Biochem/physiol Actions: Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.
Biochem/physiol Actions: Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
RIDADR UN 1993 / PGIII
WGK Germany WGK 2
Flash Point(F) 188.6 °F - closed cup - Sol
Flash Point(C) 87 °C - closed cup - Solven
Storage Temp. −20°C
UNSPSC 51102829

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