Chromomycin A₃ from Streptomyces griseus

SIGMA/C2659 - ≥95% (HPLC)

Synonym: Aburamycin B; CMA₃; NSC 58514

CAS Number: 7059-24-7
Empirical Formula (Hill Notation): C₅₇H₈₂O₂₆
Molecular Weight: 1183.25
EC Number: 230-348-0
MDL Number: MFCD00043151
Linear Formula: C₅₇H₈₂O₂₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C2659-5MG	5 mg	$321.00 1/EA		Add To Favorites
45-C2659-10MG	10 mg	$513.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
	Gram-positive bacteria
	neoplastics
assay	≥95% (HPLC)
form	powder
InChI	1S/C57H82O26/c1-21-34(79-40-19-37(53(26(6)75-40)77-28(8)59)82-38-16-33(61)52(70-11)25(5)74-38)15-31-13-30-14-32(54(71-12)51(68)46(63)22(2)58)55(50(67)44(30)49(66)43(31)45(21)62)83-41-18-35(47(64)24(4)73-41)80-39-17-36(48(65)23(3)72-39)81-42-20-57(10,69)56(27(7)76-42)78-29(9)60/h13,15,22-27,32-33,35-42,46-48,52-56,58,61-66,69H,14,16-20H2,1-12H3/t22-,23-,24+,25-,26-,27-,32-,33-,35+,36-,37-,38?,39?,40?,41?,42?,46-,47+,48-,52+,53+,54+,55-,56-,57-/m0/s1
InChI key	ZYVSOIYQKUDENJ-MTPXVABGSA-N
mode of action	DNA synthesis \| interferes
Quality Level	200
SMILES string	CO[C@H]1[C@@H](O)CC(O[C@H]1C)O[C@H]2CC(O[C@@H](C)[C@H]2OC(C)=O)Oc3cc4cc5C[C@@H]([C@@H](OC)C(=O)[C@@H](O)[C@H](C)O)[C@H](OC6C[C@@H](OC7C[C@H](OC8C[C@](C)(O)[C@@H](OC(C)=O)[C@H](C)O8)[C@@H](O)[C@H](C)O7)[C@H](O)[C@@H](C)O6)C(=O)c5c(O)c4c(O)c3C
storage temp.	−20°C

Application:	Chromomycin A3 from Streptomyces griseus has been used as a reagent in flow sorting. It has also been used to stain spermatozoa to evaluate the sperm nuclear chromatin integrity.
Biochem/physiol Actions:	Chromomycin A3 from Streptomyces griseus is an antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities. It serves as a fluorescent DNA stain. It is useful for the detection of protamine deficiency in sperm chromatin. The compound blocks macromolecule synthesis by a specific, reversible interaction with DNA in the presence of bivalent metal ions. Binding to DNA minor groove mediates an efficient competitive inhibition of DNA gyrase and significantly affects topoisomerase II activity.
Features and Benefits:	This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description:	Chemical structure: aureolic acid
Packaging:	5, 10 mg in serum bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P264 - P270 - P301 + P310 - P405 - P501
Hazard Codes	T+
Risk Statements	61-28
Safety Statements	53-28-36/37/39-45
RIDADR	UN 3462 6.1 / PGI
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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