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Cortisone

SIGMA/C2755 - ≥95%

Synonym: 17α,21-Dihydroxy-4-pregnene-3,11,20-trione; 17α-Hydroxy-11-dehydrocorticosterone; 4-Pregnene-17α,21-diol-3,11,20-trione; Kendall’s Compound E; Reichstein’s Substance Fa

CAS Number: 53-06-5
Empirical Formula (Hill Notation): C21H28O5
Molecular Weight: 360.44
EC Number: 200-162-4
MDL Number: MFCD00003610
Linear Formula: C21H28O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C2755-250MG 250 mg
 $31.20
1/EA		 Add To Favorites
45-C2755-1G 1 g
 $77.20
1/EA		 Add To Favorites
45-C2755-5G 5 g
 $240.00
1/EA		 Add To Favorites

 

assay ≥95%
biological source synthetic
form powder
InChI 1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
InChI key MFYSYFVPBJMHGN-ZPOLXVRWSA-N
mp 223-228 °C (dec.) (lit.)
Quality Level 200 
shipped in ambient
SMILES string C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)CC(=O)[C@H]23
solubility chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
sterility non-sterile
storage temp. room temp
technique(s) inhibition assay: suitable
Application: Cortisone has been used:
• to validate a 1β-HSD1 (11β-hydroxysteroid dehydrogenase type 1) inhibitor
• to study the sensitivity of erythropoietic and granulopoietic progenitor cells to cortisone
• in the determination of rates of cortisol oxidation by 11βHSD
Biochem/physiol Actions: Cortisone (11 dehydro 17 hydroxycortico-sterone) is an anti-inflammatory glucocorticoid that delays wound healing after surgeries. It postpones the healing process by affecting the appearance of inflammatory cells, ground substance, fibroblasts, collagen, regenerating capillaries, and epithelial migration. Glucocorticoids have anti-inflammatory, anti-allergic and immunosuppressive properties and are extensively used in treatment and therapy.
Biochem/physiol Actions: Cortisone is a glucocorticoid; a corticosterone analog that has approximately twice the anti-inflammatory potency as corticosterone but much lower Na2+ retention potency.
Packaging: 1, 5 g in glass bottle
Packaging: 250 mg in glass bottle
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
Purity ≥95%
mp 223-228 °C (dec.) (lit.)
Storage Temp. room temp
UNSPSC 51111800

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