Corticotropin Releasing Factor Antagonist
SIGMA/C2917 - ≥97% (HPLC)
Synonym: α-Helical CRF (9-41); α-Helical corticotropin releasing factor fragment (9-41)
CAS Number: 99658-03-4
Empirical Formula (Hill Notation): C166H274N46O53S2
Molecular Weight: 3826.36
MDL Number: MFCD00081543
Linear Formula: C166H274N46O53S2
Product Type: Chemical
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| assay | ≥97% (HPLC) |
| form | powder |
| Quality Level | 200  |
| storage temp. | −20°C |
| Amino Acid Sequence: | Asp-Leu-Thr-Phe-His-Leu-L |
| Biochem/physiol Actions: | Exhibits 10-fold higher affinity for rat CRF2α receptors over human CRF2α receptors. |
| Biochem/physiol Actions: | The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF2α receptors over human CRF2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion. |
| Other Notes: | Lyophilized from 0.1% TFA in H2O |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |