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Chelerythrine chloride

SIGMA/C2932 - ≥95% (TLC), powder

Synonym: 1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride; Toddaline chloride

CAS Number: 3895-92-9
Empirical Formula (Hill Notation): C21H18ClNO4
Molecular Weight: 383.82
MDL Number: MFCD00060717
Linear Formula: C21H18ClNO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C2932-1MG 1 mg
 $72.10
1/EA		 Add To Favorites
45-C2932-5MG 5 mg
 $171.00
1/EA		 Add To Favorites

 

assay ≥95% (TLC)
biological source plant
color yellow to orange
form powder
InChI 1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H
InChI key SUPBMPBJXZDANZ-UHFFFAOYSA-N
mp 213.0-214.0  °C
Quality Level 100 
SMILES string Cl.COc1ccc2-c3ccc4cc5OCOc5cc4c3[N](C)=Cc2c1OC
solubility DMSO: 2 mg/mL
storage temp. −20°C
Application: Chelerythrine chloride has been used:
• as a supplement in heat-inactivated late-embryo extract or late-embryo extract to inhibit protein kinase C (PKC) activity
• for in vitro Xenopus experiments
• as a PKC inhibitor in HL-1 cells, to block the PKC pathway to study its effects on doxazosin-induced galectin-3 and collagen expression
Biochem/physiol Actions: Chelerythrine chloride (CHE) is capable of preventing the growth and apoptosis in human gastric cancer BGC-823 cells. It possesses several biological effects and also can induce the phosphorylation of a ~20 kDa protein present in the mitochondrial fraction of the rat retina.
Features and Benefits: This compound is featured on the P2 Receptors: P2X Ion Channel Family  and PKC  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Chelerythrine chloride (CHE), a benzophenanthridine alkaloid is an inhibitor of protein kinase C (PKC). It is the active component of Macleaya cordata.
Packaging: 1, 5 mg in glass insert
Purity ≥95% (TLC)
mp 213.0-214.0  °C
Storage Temp. −20°C
UNSPSC 12352200

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