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CFTR(inh)-172

SIGMA/C2992 - ≥98% (HPLC), powder

Synonym: 5-[(4-Carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl-4-thiazolidinone

CAS Number: 307510-92-5
Empirical Formula (Hill Notation): C18H10F3NO3S2
Molecular Weight: 409.40
MDL Number: MFCD06411408
Linear Formula: C18H10F3NO3S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C2992-5MG 5 mg
 $196.00
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45-C2992-25MG 25 mg
 $769.00
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assay ≥98% (HPLC)
color yellow
form powder
InChI 1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8+
InChI key JIMHYXZZCWVCMI-RIYZIHGNSA-N
Quality Level 100 
SMILES string OC(=O)c1ccc(cc1)C=C2SC(=S)N(C2=O)c3cccc(c3)C(F)(F)F
solubility DMSO: ≥10 mg/mL
  H2O: insoluble
storage temp. 2-8°C
Application: CFTR(inh)-172 has been used to specifically inhibit cystic fibrosis transmembrane conductance regulator (CFTR) activity. It is also used as a CFTR inhibitor Inh-172 to treat forskolin and IBMX.
Biochem/physiol Actions: CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR).
Biochem/physiol Actions: CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a Ki = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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