Dicyanocobinamide

SIGMA/C3021 - ≥93%

Synonym: Cobinamide dicyanide; Etiocobalamin; Factor B

CAS Number: 27792-36-5
Empirical Formula (Hill Notation): C₅₀H₇₂CoN₁₃O₈
Molecular Weight: 1042.12
MDL Number: MFCD00056330
Linear Formula: C₅₀H₇₂CoN₁₃O₈
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C3021-10MG	10 mg	$248.00 1/EA	Add To Favorites
45-C3021-50MG	50 mg	$844.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C3021-50MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥93%
biological source	synthetic (organic)
color	purple to very dark purple
form	powder
impurities	≤0.1% vitamin B₁₂
InChI	1S/C48H73N11O8.2CN.Co/c1-23(60)22-55-38(67)16-17-45(6)29(18-35(52)64)43-48(9)47(8,21-37(54)66)28(12-15-34(51)63)40(59-48)25(3)42-46(7,20-36(53)65)26(10-13-32(49)61)30(56-42)19-31-44(4,5)27(11-14-33(50)62)39(57-31)24(2)41(45)58-43;2*1-2;/h19,23,26-29,43,59-60H,10-18,20-22H2,1-9H3,(H2,49,61)(H2,50,62)(H2,51,63)(H2,52,64)(H2,53,65)(H2,54,66)(H,55,67);;;/b30-19-,39-24-,40-25-;;;/t23-,26+,27+,28+,29-,43?,45+,46-,47-,48-;;;/m0.../s1
InChI key	NJATWHPHZUGTHR-GXEWULDJSA-N
Quality Level	200
SMILES string	N#C[Co]C#N.C[C@H](O)CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)C2N=C1C(C)=C3N=C(C=C4N=C(C(C)=C5N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O
storage temp.	−20°C

Application:	Dicyanocobinamide has been used for the crystallization of vitamin B₁₂-binding protein (BtuF). It has also been used for the destabilization of BtuCD-BtuF Interaction.
Application:	For use in determining non-intrinsic factor (R protein) in intrinsic factor preparations.
Biochem/physiol Actions:	Dicyanocobinamide (Cbi) functions as a soluble guanylate cyclase (sGC) co-activator and targets the N-terminal regulatory regions. This action is similar to the effect of forskolin on adenylyl cyclases. Dicyanocobinamide elevates the intracellular cyclic guanosine monophosphate (cGMP) levels and exhibits vasorelaxant activity in rats. It is used along with various cobalamins in studies of the inhibition of HIV-1 integrase and nitric oxide synthase.
General description:	Dicyanocobinamide, also known as factor b is a coenzyme B12 precursor. It has a corrin ring structure with four of the six coordination sites of the cobalt (Co) atom being the pyrrole nitrogen atoms.
Packaging:	10, 50 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22-68
Safety Statements	36-37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥93%
Storage Temp.	−20°C
UNSPSC	12352205

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