Corticotropin Releasing Factor human, rat
SIGMA/C3042 - ≥95% (HPLC), powder
Synonym: CRF; CRH
CAS Number: 86784-80-7
Empirical Formula (Hill Notation): C208H344N60O63S2
Molecular Weight: 4757.45
MDL Number: MFCD00213806
Linear Formula: C208H344N60O63S2
Product Type: Chemical
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| assay | ≥95% (HPLC) |
| biological source | human |
| rat | |
| form | powder |
| InChI key | VXFVFWFSJFSXHN-FAUHKOHMSA |
| mol wt | 4757.45 |
| Quality Level | 200  |
| solubility | water: 1.00-1.04 mg/mL, colorless |
| storage condition | (Keep container tightly closed in a dry and well-ventilated place) |
| storage temp. | −20°C |
| technique(s) | activity assay: suitable |
| UniProt accession no. | P06850  |
| Amino Acid Sequence: | Ser-Glu-Glu-Pro-Pro-Ile-S |
| Application: | Corticotropin Releasing Factor human, rat has been used: • as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants • as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells • in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixtu • in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus |
| Biochem/physiol Actions: | Corticotropin-releasing factor modulates stress responses. It facilitates stress-stimulated activation of the hypothalamic−pituitary−ad |
| Biochem/physiol Actions: | CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress. |
| Biochem/physiol Actions: | Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter. |
| General description: | The corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, the hypothalamus, and the amygdala. Research area: Neuroscience |
| Other Notes: | Lyophilized from 0.1% TFA in H2O |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |