Cholesterol
SIGMA/C3045 - powder, BioReagent, suitable for cell culture, ≥99%
Synonym: 3β-Hydroxy-5-cholestene; 5-Cholesten-3β-ol
CAS Number: 57-88-5
Empirical Formula (Hill Notation): C27H46O
Molecular Weight: 386.65
EC Number: 200-353-2
MDL Number: MFCD00003646
Linear Formula: C27H46O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C3045-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C3045-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C3045-5G
| assay | ≥99% |
| biological source | ovine wool |
| bp | 360 °C (lit.) |
| density | 1.067 g/mL at 25 °C (lit.) |
| form | powder |
| InChI | 1S/C27H46O/c1-18(2)7-6-8- |
| InChI key | HVYWMOMLDIMFJA-DPAQBDIFSA |
| mp | 147-149 °C (lit.) |
| product line | BioReagent |
| Quality Level | 200  |
| shipped in | ambient |
| SMILES string | CC(C)CCC[C@@H](C)[C@H]1CC |
| solubility | ethanol: soluble |
| H2O: 0.002 mg/mL | |
| serum: soluble | |
| Tween: soluble | |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| Application: | Cholesterol has been used: • as a medium supplement in chorionic villous tissue culture form placenta • as a component of hormone pellet for implantation in mice ovary • for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1 |
| Biochem/physiol Actions: | Major component of all biological membranes; ~25% of total brain lipid is cholesterol. |
| General description: | Cholesterol, a major sterol is the precursor for steroid hormones, bile acid and vitamin in mammals and coordinates endocytosis. It complexes with protein to form lipoproteins for transport in blood. It exists either as high-density lipoprotein (HDL) or low-density lipoprotein (LDL). HDL also called good cholesterol has less lipid content. LDL or bad cholesterol has high lipid content. Statin inhibition of HMG-CoA reductase enzyme in the cholesterol biosynthesis pathway controls elevated cholesterol levels in atherosclerosis and hypercholesterolemia. Low levels of cholesterol results in hypothyroidism, familial hypobetalipoproteinemia and liver disease. Imbalance of cholesterol homeostasis and intracellular cholesterol levels play a key role in cancer development. High cholesterol levels favor breast cancer progression. |
| Packaging: | 5, 25, 100 g in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% |
| bp | 360 °C (lit.) |
| mp | 147-149 °C (lit.) |
| Density | 1.067 g/mL at 25 °C (lit.) |
| Storage Temp. | −20°C |
| UNSPSC | 12352211 |