Coenzyme A sodium salt hydrate
SIGMA/C3144 - cofactor for acyl transfer
Synonym: CoA Na2
CAS Number: 55672-92-9 (anhydrous)
Empirical Formula (Hill Notation): C21H36N7O16P3S · xNa+ · yH2O
Molecular Weight: 767.53 (anhydrous free acid basis)
EC Number: 259-747-8
MDL Number: MFCD00079020
Linear Formula: C21H36N7O16P3S · xNa+ · yH2O
Product Type: Chemical
Coenzyme A (CoA, CoASH or HSCoA) is the key cofactor in first step of the TCA cycle, responsible for transferring the acetyl group from pyruvate oxidation to oxaloacetate yielding citrate. Coenzyme A is also a critical cofactor in fatty acid metabolism. Coenzyme A carries fatty acids through the catabolic/oxidation process in the mitochondria and transfers acetyl groups during the elongation process of fatty acid synthesis in the cytosol.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C3144-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C3144-500MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C3144-1G
| assay | ≥85% (spectrophotometric assay) |
| description | cofactor for acyl transfer |
| form | powder |
| InChI key | SYTRWOCXZXQBPW-CLVRNSBASA |
| Quality Level | 200  |
| SMILES string | [Na+].CC(C)(COP(O)(=O)OP( |
| solubility | H2O: soluble 50 mg/mL, clear, colorless to faintly yellow |
| storage temp. | −20°C |
| Application: | Coenzyme A is suitable for use in: • gylcerolipid biosynthesis in porcine adipose tissue • an assay to measure the level of Alpha-methylacyl-CoA racemase (AMACR) in human blood samples using a nanoparticle electrochemical biosensor • chloramphenicol acetyltransferase (CAT) assay • the synthesis of palmitoyl-CoA, which is required for palmitoylation and activation of proteins for regulated membrane fusion |
| Biochem/physiol Actions: | Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes. In the presence of CoASH, organic carboxylic acids form acyl-CoA thioesters, which facilitates enzyme recognition. The acyl-CoA formed from xenobiotic carboxylic acids can add to the compound′s toxicity, which can lead to cellular metabolic dysfunction. It is involved in the oxidation of pyruvate in the Kreb′s cycle. CoA is needed for metabolic events. The bacterial CoA pathway is targeted for antimicrobial development. It mediates acyl group transfer and carbonyl activation. The CoA and its thioester levels are crucial for cellular homeostasis. CoA is also involved in regulating platelet aggregation and vasoconstriction. It acts as an essential cofactor in enzymatic acetyl transfer reactions. |
| General description: | Coenzyme A (CoA) is an essential cofactor in living systems and is synthesized from pantothenic acid (vitamin B5), The CoA levels in mitochondria and peroxisomes correspond to 2-5 mM and 0.7 mM, respectively. Cytosolic CoA is in the range of 0.05 mM to 0.14 mM |
| Packaging: | 1 g in poly bottle |
| Packaging: | 10 mg in glass bottle |
| Packaging: | 25, 100, 500 mg in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥85% (spectrophotometric assay) |
| Storage Temp. | −20°C |
| UNSPSC | 41106305 |