Complement C9 from human serum
SIGMA/C3660 - ≥150,000 C9H50 units/mg (using C9 deficient serum)
CAS Number: 80295-59-6
MDL Number: MFCD00130849
Product Type: Chemical
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| application(s) | cell analysis |
| assay | ≥85% (SDS-GE) |
| biological source | human |
| form | solution |
| Quality Level | 200  |
| shipped in | dry ice |
| specific activity | ≥150,000 C9H50 units/mg (using C9 deficient serum) |
| storage temp. | −70°C |
| UniProt accession no. | P02748  |
| Analysis Note: | Functionally pure by a sensitive hemolytic assay using deficient sera. |
| Application: | Complement C9 from human serum is an essential part of the terminal complement system. It has been a topic in cancer research, where extracellular phosphorylation by ecto-PK of K562 cells on serine residues may serve as a protective mechanism against complement in tumor cells. Additionally, it can be used as a biomarker (in fucosylated form) for squamous cell lung cancer, as patients tend to show elevated levels of C9 protein. |
| Biochem/physiol Actions: | Complement component C9 is the final component of the membrane attack complex (MAC) responsible for cell lysis by complement. CD59 binds to both C8 and C9 and prevents assembly of an active MAC, protecting cells against lytic activity. |
| Disclaimer: | RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization. |
| Other Notes: | View more information on the complement pathway at www.sigma-aldrich.com/enz |
| Physical form: | Supplied as a solution in phosphate buffered saline, pH 7.2. |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥85% (SDS-GE) |
| activity | specific activity: ≥150,000 C9H50 units/mg (using C9 deficient serum) |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |