Cyclosporin A

SIGMA/C3662 - from Tolypocladium inflatum, ≥95% (HPLC), solid

Synonym: Antibiotic S 7481F1; Cyclosporine

CAS Number: 59865-13-3
Empirical Formula (Hill Notation): C₆₂H₁₁₁N₁₁O₁₂
Molecular Weight: 1202.61
MDL Number: MFCD00274558
Linear Formula: C₆₂H₁₁₁N₁₁O₁₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C3662-5MG	5 mg	$203.00 1/EA	Add To Favorites
45-C3662-10MG	10 mg	$377.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C3662-10MG

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
assay	≥95% (HPLC)
biological source	Tolypocladium inflatum
color	white
form	solid
InChI	1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
InChI key	PMATZTZNYRCHOR-CGLBZJNRSA-N
mode of action	enzyme \| inhibits
originator	Novartis
Quality Level	300
SMILES string	CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)CC=CC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
solubility	chloroform: 6 mg/mL
	dichloromethane: 10 mg/mL
	DMSO: 50 mg/mL
	ethanol: 10 mg/mL
	H₂O: insoluble
storage temp.	2-8°C

Biochem/physiol Actions:	A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
Biochem/physiol Actions:	Potent immunosuppressant; inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα; blocks cytochrome c release from mitochondria.
Features and Benefits:	This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	5, 10 mg in glass bottle

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H302 - H350 - H360FD
Precautionary statements	P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
Hazard Codes	T
Risk Statements	45-60-22
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥95% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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