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Chk2 Inhibitor II hydrate

SIGMA/C3742 - ≥98% (HPLC)

Synonym: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate

CAS Number: 516480-79-8 (anhydrous)
Empirical Formula (Hill Notation): C20H14ClN3O2 · xH2O
Molecular Weight: 363.80 (anhydrous basis)
MDL Number: MFCD08276917
Linear Formula: C20H14ClN3O2 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C3742-5MG 5 mg
 $226.00
1/EA		 Add To Favorites
45-C3742-25MG 25 mg
 $908.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color off-white to tan
form solid
InChI 1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
InChI key UXGJAOIJSROTTN-UHFFFAOYSA-N
originator Johnson & Johnson
Quality Level 100 
SMILES string O=C(C1=CC=C2C(N=C(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)N2)=C1)N
solubility DMSO: ≥2 mg/mL (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer.
Biochem/physiol Actions: Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively).
Features and Benefits: This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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