Chloramphenicol succinate sodium salt

SIGMA/C3787 - ≥80% (HPLC)

Synonym: Chloramphenicol α-succinate

CAS Number: 982-57-0
Empirical Formula (Hill Notation): C₁₅H₁₅Cl₂N₂NaO₈
Molecular Weight: 445.18
EC Number: 213-568-1
MDL Number: MFCD00079025
Linear Formula: C₁₅H₁₅Cl₂N₂O₈Na
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C3787-5G	5 g	$75.80 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
assay	≥80% (HPLC)
form	solid
InChI	1S/C15H16Cl2N2O8.Na.H/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26;;/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21);;/t10-,13-;;/m1../s1
InChI key	RJOAHMNSYANTPN-OWVUFADGSA-N
mode of action	protein synthesis \| interferes
Quality Level	100
SMILES string	[Na].O[C@@H]([C@@H](COC(=O)CCC(O)=O)NC(=O)C(Cl)Cl)c1ccc(cc1)N(=O)=O
solubility	H₂O: 50 mg/mL

Application:	Chloramphenicol is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.
Biochem/physiol Actions:	Chloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription. Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it. Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.
Disclaimer:	Stock solutions should be stored at 2-8°C and are stable at 37°C for 5 days. Aqueous solutions are neutral and stable over a wide pH range, with 50% hydrolysis occurring after 290 days. Use of a borax buffered solution reduces this number to 14%. Solutions should be protected from light as photochemical decomposition results in a yellowing of the solution. Heating aqueous solutions at 115°C for 30 minutes results in a 10% loss of chloramphenicol.
General description:	Chemical structure: phenicole
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.
Packaging:	5, 25, 100 g in glass bottle
Preparation Note:	Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH.

Symbol	GHS07,GHS08
Signal word	Warning
Hazard statements	H302 - H351
Precautionary statements	P201 - P301 + P312 + P330 - P308 + P313
Hazard Codes	Xn
Risk Statements	40
Safety Statements	22-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥80% (HPLC)
UNSPSC	41116107

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