Cyclophilin A human
SIGMA/C3805 - ≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution
Synonym: CyP
CAS Number: 95076-93-0
MDL Number: MFCD00130885
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| concentration | ≥0.3 mg/mL |
| form | buffered aqueous solution |
| mol wt | 20 kDa |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P62937  |
| Application: | Cyclophilin A human has been used in the study to interpret the mechanisms by which extracellular CyPA initiates endothelial activation. |
| Biochem/physiol Actions: | Cyclophilin A (CyPA) participates in intracellular signalling and protein trafficking. It helps to control other proteins activity. CyPA plays a physiological and pathological role in cardiovascular diseases. Hence it acts as an important biomarker and mediator in several cardiovascular diseases, like vascular stenosis, atherosclerosis and abdominal aortic aneurysms. CyPA can induce the proliferation and inflammatory cell migration of vascular smooth muscle cells (VSMC) in vitro and in vivo. |
| Biochem/physiol Actions: | Cyclophilins are peptidyl prolyl isomerases that catalyze the cis-trans isomerization of X-Pro peptide bonds. They are highly-conserved cytoplasmic enzymes that accelerate protein folding and facilitate HIV infectivity. Cyclosporin A binds to cyclophilin and inhibits its activity. The cyclosporin A-cyclophilin complex binds to calcineurin and inhibits T-cell activation. The structure of human, recombinant cyclophilin is given by Holzman, et al. |
| General description: | Cyclophilins are a family of extremely conserved proteins, known as immunophilins. Cyclophilin A (CyPA) is present in all tissues in prokaryotes and eukaryotes. It is present in all organs of human. Cyclophilin A (CyPA), a 20 kDa chaperone protein, that is liberated from vascular smooth muscle cells (VSMCs). |
| Physical form: | Composed of amino acids 1-165 plus an N-terminal 20 amino acid His-tag |
| Physical form: | Solution in 20mM Tris, pH 8.0, containing 20 mM NaCl, 0.5 mM DTT and 10% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| Enzyme Commission (EC) Number | 5.2.1.8 ( BRENDA | IUBMB ) |
| UNSPSC | 12352204 |