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Cucurbitacin I hydrate

SIGMA/C4493 - ≥95% (HPLC), solid

Synonym: 2,16α,20,25-Tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione; Elatericin B; JSI-124; NSC 521777

CAS Number: 2222-07-3 (anhydrous)
Empirical Formula (Hill Notation): C30H42O7 · xH2O
Molecular Weight: 514.65 (anhydrous basis)
EC Number: 218-736-8
MDL Number: MFCD09971044
Linear Formula: C30H42O7 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C4493-1MG 1 mg
 $293.91
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This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C4493-1MG.

 

assay ≥95% (HPLC)
color white to off-white
form solid
InChI 1S/C30H42O7.H2O/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6;/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3;1H2/b12-11+;/t17-,19-,20+,23+,27+,28-,29+,30+;/m1./s1
InChI key ZKDSPEWKSJCXQE-NEBRQAMTSA-N
Quality Level 100 
SMILES string O.CC(C)(O)C=CC(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C
solubility DMSO: >5 mg/mL
storage temp. −20°C
Biochem/physiol Actions: Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties.
Biochem/physiol Actions: Cucurbitacin I is a novel selective JAK/STAT3 inhibitor.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the JAKs  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 1 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H300
Precautionary statements P264 - P301 + P310
Hazard Codes T+
Risk Statements 28
Safety Statements 28-36/37-45
RIDADR UN 2811 6.1 / PGI
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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