Carboxylesterase 2 human
SIGMA/C4749 - recombinant, expressed in mouse NSO cells, ≥95% (SDS-PAGE)
Synonym: CES2; CES2A1
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| assay | ≥95% (SDS-PAGE) |
| concentration | 0.4-0.6 mg/mL |
| form | solution |
| impurities | ≤1.0 EU/μg endotoxin |
| mol wt | predicted mol wt ~60 kDa |
| NCBI accession no. | NM_003869   |
| NP_003860 |
|
| Quality Level | 200 |
| recombinant | expressed in mouse NSO cells |
| shipped in | dry ice |
| specific activity | ≥1.0 EU/μg |
| 30,000 pmol/min-μg protein | |
| storage temp. | −70°C |
| Biochem/physiol Actions: | Human carboxylesterase 2 (hCE-2) recognizes a substrate with a large alcohol group and small acyl group. Its substrate specificity may be restricted by a capability of acyl-hCE-2 conjugate formation due to the presence of conformational interference in the active site pocket. Carboxylesterases catalyze the biotransformation of several ester-containing drugs and prodrugs such as angiotensin-converting enzyme inhibitor (temocarpil, cilazapril), anti-tumor drugs (capecitabin) and narcotics. |
| Biochem/physiol Actions: | Member of a serine esterase family that hydrolyze ester and amide bonds. Carboxylesterase 2 is an endoplasmic reticulum-bound hydrolase that plays a critical role in xenobiotic detoxification and activation for ester-containing therapeutics. Carboxylesterase 2 is also involved in the detoxification of drugs such as heroin and cocaine. This enzyme is thought to play a role in lipid metabolism. |
| Other Notes: | One unit will cause the hydrolysis of 1 picomole of p-nitrophenylacetate per minute at pH 7.5 at 25 deg C. |
| Physical form: | Supplied as a solution containing sodium chloride, sodium acetate, and 20% glycerol. |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H334 |
| Precautionary statements | P261 - P284 - P501 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| activity | specific activity: ≥1.0 EU/μg; specific activity: 30,000 pmol/min-μg protein |
| Storage Temp. | −70°C |
| Enzyme Commission (EC) Number | 3.1.1.1 ( BRENDA | IUBMB ) |
| UNSPSC | 12352204 |