Coenzyme A sodium salt hydrate

SIGMA/C4780 - BioReagent, suitable for cell culture

Synonym: CoA Na₂

CAS Number: 55672-92-9 (anhydrous)
Empirical Formula (Hill Notation): C₂₁H₃₆N₇O₁₆P₃S · xNa⁺ · yH₂O
Molecular Weight: 767.53 (anhydrous free acid basis)
EC Number: 259-747-8
MDL Number: MFCD00079020
Linear Formula: C₂₁H₃₆N₇O₁₆P₃S · xNa⁺ · yH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C4780-10MG	10 mg	$94.30 1/EA	Add To Favorites
45-C4780-25MG	25 mg	$152.00 1/EA	Add To Favorites
45-C4780-100MG	100 mg	$451.00 1/EA	Add To Favorites

Coenzyme A (CoA, CoASH or HSCoA) is the key cofactor in first step of the TCA cycle, responsible for transferring the acetyl group from pyruvate oxidation to oxaloacetate yielding citrate. Coenzyme A is also a critical cofactor in fatty acid metabolism. Coenzyme A carries fatty acids through the catabolic/oxidation process in the mitochondria and transfers acetyl groups during the elongation process of fatty acid synthesis in the cytosol.

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥85% (HPLC)
biological source	yeast
description	cofactor for acyl transfer
form	powder
InChI	1S/C21H36N7O16P3S.Na/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H
InChI key	SYTRWOCXZXQBPW-CLVRNSBASA-M
product line	BioReagent
Quality Level	200
SMILES string	[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
solubility	water: 50 mg/mL, clear, colorless to faintly yellow
storage temp.	−20°C
technique(s)	cell culture \| mammalian: suitable

Analysis Note:	Enzymatically assayed using phosphotransacetylase. Approx. 95% CoA-SH
Application:	Coenzyme A sodium salt hydrate has been used: • in the branch chain aminotransferase enzymatic assay and protein determination • in the assay for halogenation of pyrrolyl-S-Bmp1 (an acyl carrier protein (ACP)-thioesterase (TE) di-domain protein) by Bmp2 • as an extracellular coenzyme A (CoA) in in vitro and in vivo experiments to study alternative routes by which cells and organisms can obtain CoA
Biochem/physiol Actions:	Coenzyme A (CoA) is a ubiquitous cofactor that plays an important role in many metabolic pathways, mainly as acyl-CoA. It is essential for the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. CoA facilitates acyl group transfers, especially in fatty acid and lipid metabolism reactions. It is associated with neurodegeneration, autophagy, protein acetylation, and signal transduction.
Packaging:	10, 25, 100 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥85% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352205

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