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Calmodulin bovine

SIGMA/C4874 - recombinant, expressed in E. coli, lyophilized powder, ≥98% (SDS-PAGE)

Synonym: CaM, Phosphodiesterase 3:5-cyclic nucleotide activator; Phosphodiesterase 3′:5′-cyclic nucleotide activator

MDL Number: MFCD00131869
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C4874-0.2MG 0.2 mg
 $112.00
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45-C4874-0.5MG 0.5 mg
 $194.00
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45-C4874-1MG 1 mg
 $363.00
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45-C4874-2MG 2 mg
 $663.00
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SDS-PAGE Purity of Calmodulin Bovine (Cat. No. C4874) was assessed on SDS-PAGE. Lanes: 1. 1 μg/mL 2. 0.5 μg/mL

 

assay ≥98% (SDS-PAGE)
biological source bovine
composition Protein, ≥85%
form lyophilized powder
mol wt Mw 19000.9 by amino acid sequence
Quality Level 200 
recombinant expressed in E. coli
storage temp. −20°C
UniProt accession no. P62157 
Application: Calmodulin bovine has been used inin vitro phosphorylation assay of recombinant retinoic acid-inducible gene I protein. It has also been used in the endoprotease Glu-C proteolysis and deamidation studies.
Biochem/physiol Actions: Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP-ribose and is involved in intracellular Ca2+ homeostasis.
Biochem/physiol Actions: Calmodulin from bovine undergoes conformational changes upon calcium binding. It binds to sphingosylphosphorylcholine and inhibit calcineurin and phosphodiesterase enzymes.
General description: Calmodulin from bovine takes up a dumb-bell-structure. Two calcium binding EF hand loops, antiparallel β-sheet and three α-helices comprises a lobe. It has a central helix connecting the lobes. Calmodulin can bind four calcium molecules in a cooperative interaction pattern.
General description: Sequence:
MGSSHHHHHHSSGLVPRGSHMADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Preparation Note: Produced using animal component-free materials.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (SDS-PAGE)
Storage Temp. −20°C
UNSPSC 12352202

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