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Chlortetracycline hydrochloride

SIGMA/C4881 - ≥91.0% dry basis (HPLC)

Synonym: 7-Chlorotetracycline hydrochloride

CAS Number: 64-72-2
Empirical Formula (Hill Notation): C22H23ClN2O8 · HCl
Molecular Weight: 515.34
EC Number: 200-591-7
MDL Number: MFCD00082440
Linear Formula: C22H23ClN2O8 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C4881-5G 5 g
 $62.90
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45-C4881-25G 25 g
 $156.00
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45-C4881-100G 100 g
 $480.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C4881-5G

 

antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
assay ≥91.0% dry basis (HPLC)
form powder
InChI 1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7?,8-,15-,21-,22-;/m0./s1
InChI key CBHYYLPALVVVEY-LYNLVHCPSA-N
mode of action protein synthesis | interferes
mp 210-215 °C (dec.) (lit.)
pKa (25 °C) 3.3
  7.4
  9.3
Quality Level 200 
SMILES string Cl.CN(C)[C@H]1[C@@H]2CC3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O
solubility 1 M NaOH: 50 mg/mL
storage temp. −20°C
Application: Chlortetracycline was used in fluorescence assays to detect the Ca+2 influx required for the completion of acrosome reaction in human spermatozoa.
Biochem/physiol Actions: Chlortetracycline is an antibiotic produced by some strains of Streptomyces aureofaciens. It inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit. It is effective against Gram-positive and to a lesser degree Gram-negative bacteria than tetracycline.
Mode of Resistance: Loss of cell wall permeability.
General description: Chemical structure: tetracycline
Other Notes: If stored frozen, chlortetracycline hydrochloride is expected to remain stable at least four years.
Packaging: 5, 25, 100 g in glass bottle
Purity ≥91.0% dry basis (HPLC)
mp 210-215 °C (dec.) (lit.)
Storage Temp. −20°C
UNSPSC 51102829

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