Cephalexin hydrate

SIGMA/C4895 - first-generation cephalosporin antibiotic

CAS Number: 1820673-23-1
Empirical Formula (Hill Notation): C₁₆H₁₇N₃O₄S · xH₂O
Molecular Weight: 347.39 (anhydrous basis)
EC Number: 239-773-6
MDL Number: MFCD00056877
Linear Formula: C₁₆H₁₇N₃O₄S · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C4895-5G	5 g	$143.00 1/EA		Add To Favorites
45-C4895-10G	10 g	$254.00 1/EA		Add To Favorites
45-C4895-25G	25 g	$490.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
form	powder
InChI	1S/C16H17N3O4S.H2O/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23);1H2/t10-,11-,15?;/m1./s1
InChI key	AVGYWQBCYZHHPN-FNOHQHCYSA-N
mode of action	cell wall synthesis \| interferes
pKa	5.2
	7.3
Quality Level	200
SMILES string	S1C2N(C(=C(C1)C)C(=O)O)C(=O)[C@H]2NC(=O)[C@H](N)c3ccccc3.O
storage temp.	2-8°C

Application:	Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions:	Cephalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cephalexin antibiotics mimic the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan.
General description:	Chemical structure: ß-lactam
Other Notes:	Storage of this product should be in airtight containers and protected from light.

Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	22-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	51282503

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