Carnitine Acetyltransferase from pigeon breast muscle
SIGMA/C4899 - ammonium sulfate suspension, ≥50 units/mg protein
Synonym: CATC; Carnitine acetyltransferase; Acetyl-
CAS Number: 9029-90-7
MDL Number: MFCD00130725
Product Type: Chemical
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| biological source | pigeon breast |
| concentration | ≥0.4 mg/mL |
| form | ammonium sulfate suspension |
| Protein ID accession no. | AAA80570.1   |
| Quality Level | 200 |
| specific activity | ≥50 units/mg protein |
| storage temp. | 2-8°C |
| technique(s) | cell based assay: suitable |
| UniProt accession no. | P52826 |
| Analysis Note: | Protein determined by biuret. |
| Application: | Carnitine Acetyltransferase from pigeon breast muscle has been used in enzymatic assays. |
| Biochem/physiol Actions: | Carnitine acetyltransferase maintains the cellular and mitochondrial levels of acetyl-CoA, a key cofactor required for oxidative metabolism, by catalyzing an equilibrium between acetyl-CoA and acetyl-L-carnitine, a storage form of activated acetate. Carnitine acetyltransferase also maintains the pool of acetyl-CoA required for neuronal and nonneuronal acetylcholine production. |
| Biochem/physiol Actions: | Carnitine acyltransferases (CrAT) are enzymes that contribute to the reversible conversion of acetyl-CoA and carnitine into acetylcarnitine and free CoA. This enzymatic process plays a vital role in the energy metabolism of eukaryotes by promoting the β-oxidation of fatty acids. CrAT-mediated acetyl carnitine production and efflux help maintain a balance between acetyl-CoA and acetyl carnitine in the mitochondria, regenerate free CoA, and alleviate the product inhibition of pyruvate dehydrogenase (PDH), which is a key enzyme in glucose oxidation. This process promotes glucose homeostasis and helps maintain optimal cellular energy metabolism. Carnitine acetyltransferase activity also aids in the progression of the cell cycle from G1 to S phase. carnitine acetyltransferase deficiency also leads to the development of various neurological disorders including Alzheimer′s disease, ataxic encephalopathy, and several vascular diseases. |
| General description: | Research area: Cell Signaling |
| Other Notes: | One unit will convert 1.0 μmole of acetyl- |
| Physical form: | Crystalline suspension in 3.2 M (NH4)2SO4 solution, 50 mM potassium phosphate, 1 mM dithiothreitol, pH 7.0 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥50 units/mg protein |
| Storage Temp. | 2-8°C |
| Enzyme Commission (EC) Number | 2.3.1.7 ( BRENDA | IUBMB ) |
| UNSPSC | 12352204 |