Anti-Calcium Channel (α2/δ-1 Subunit) antibody produced in rabbit
SIGMA/C5105 - affinity isolated antibody, lyophilized powder
Synonym: Anti-CACNA2; Anti-CACNL2A; Anti-CCHL2A; Anti-LINC01112; Anti-lncRNA-N3
MDL Number: MFCD02686000
Product Type: Chemical
Immunocytochemistry Anti-Cavα2δ1 (extracellular): Cat. No. C5105: Immunocytochemical staining of intact living Rat Pheochromocytoma (PC12) cells. A. Extracellular staining of cells using Anti-Cavα2δ1 (extracellular) antibody, (1:50), (red). B. Merge of A with the live view of the cell.
Immunoblotting Anti-Cavα2δ1 (extracellular): Cat. No. C5105: Western blot analysis of Rat brain membranes. Lanes 1. Anti-Cavα2δ1 (extracellular) antibody, (1:200). 2. Anti-Cavα2δ1 (extracellular) antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | mouse, rat, pig, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot (chemiluminescent): 1:200 using rat brain membranes |
| UniProt accession no. | P54289  |
| Application: | Anti-Calcium Channel (α2/δ-1 Subunit) antibody produced in rabbit has been used in immunoblotting and immunofluorescence. |
| Biochem/physiol Actions: | CACNA2D1 (calcium channel, voltage-dependent, α2/δsubunit 1) is a type of α2δs, which are involved in the synaptic neurotransmitter release as they are concentrated at the synapses. They have a chaperone-like activity in non-neuronal cells. This protein acts as a target for gabapentin, which is a neuropathic analgesic. Mutations in this gene, in humans result in short QT syndrome (SQTS). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | CACNA2D1 (calcium channel, voltage-dependent, α2/δ subunit 1) is a member of a family of GPI-anchored voltage-gated calcium channels (VGCCs)-associated subunits called α2δ. VGCC are composed of three types of subunits- pore-forming α1 and auxiliary β and α2δ subunits. |
| General description: | L-type of Voltage-gated Ca2+ Channel. |
| Immunogen: | synthetic peptide corresponding to amino acids 1-15 of α2 subunit (amino acids 27-41 of rabbit α2/δ−1 precursor). |
| Physical form: | Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide. |
| Preparation Note: | Reconstitute the 0.05 mL vial with 50 μL deionized water. Reconstitute the 0.2 mL vial with 0.2 mL deionized water. After reconstitution, the antibody concentration is ~0.8 mg/mL. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |