4′-Chlorodiazepam
SIGMA/C5174 - ≥98% (TLC)
Synonym: 7-
CAS Number: 14439-61-3
Empirical Formula (Hill Notation): C16H12Cl2N2O
Molecular Weight: 319.19
MDL Number: MFCD00043406
Linear Formula: C16H12Cl2N2O
Product Type: Chemical
| assay | ≥98% (TLC) |
| drug control | regulated under CDSA - not available from Sigma-Aldrich Canada; Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet |
| form | powder |
| InChI | 1S/C16H12Cl2N2O/c1-20-14- |
| InChI key | PUMYFTJOWAJIKF-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | O=C1CN=C(C2=CC=C(Cl)C=C2) |
| solubility | 2-hydroxypropyl-β-cyclode |
| H2O: insoluble |
| Application: | 4′-Chlorodiazepam has been used as a translocator protein ligand in mitochondrial functional studies. It has also been used to investigate its protective effects on glucose deprived T98G astrocyte cell lines. |
| Biochem/physiol Actions: | 4′-Chlorodiazepam (Ro5-4864) is a potent selective ligand for the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies. |
| Packaging: | 5 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (TLC) |
| UNSPSC | 12352200 |