Cinnarizine
SIGMA/C5270 - powder
Synonym: 1-trans-
CAS Number: 298-57-7
Empirical Formula (Hill Notation): C26H28N2
Molecular Weight: 368.51
EC Number: 206-064-8
MDL Number: MFCD00056037
Linear Formula: C26H28N2
Product Type: Chemical
| color | white |
| form | powder |
| InChI | 1S/C26H28N2/c1-4-11-23(12 |
| InChI key | DERZBLKQOCDDDZ-JLHYYAGUSA |
| originator | Johnson & Johnson |
| Quality Level | 100  |
| SMILES string | C1CN(CCN1CC=Cc2ccccc2)C |
| Application: | Cinnarizine has been used to block pressure-dependent changes in potassium currents in acutely isolated inner hair cells of the guinea-pig cochlea using whole-cell voltage-clamp techniques. It has also been used in the in vivo and in vitro studies, to analyze the impact of drug load and physical form of cinnarizine in self-nanoemulsifying drug delivery systems (SNEDDS) on absorption in rats. |
| Application: | Cinnarizine has been used: • to study its role in self-nano emulsifying drug delivery systems (SNEDDS)(8)(10) • to test Ca2+ signaling is pivotal for cancer-associated fibroblasts (CAFs) retraction(9) • as a model drug to develop a high-throughput in vitro intestinal lipolysis (HTP) model(11) |
| Biochem/physiol Actions: | Ca2+ channel blocker; central and peripheral vasodilator. |
| Biochem/physiol Actions: | Cinnarizine is a piperazine and a specific anti-vertigo agent. It is used to treat and prevent vertigo and motion sickness. In addition, cinnarizine is also used as an anti-histamine agent. Chronic use of this drug leads to side effects such as extrapyramidal reactions (Parkinson, tremor and akathisia) and depression. |
| Features and Benefits: | This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | Cinnarizine is a piperazine derivative, which is extracted from wood reed roots. It exhibits antihistaminic and calcium antagonist property. Cinnarizine is used to treat vertigo, unsteadiness and cognitive disorders. Cinnarizine has anticholinergic, antiserotonergic and antidopaminergic effects. It enhances cerebral blood flow. Cinnarizine blocks the contraction of smooth muscles cells and also acts as a skin whitening agent. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 12352200 |