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Chlorisondamine diiodide

SIGMA/C5366 - ≥98% (HPLC), white, solid

Synonym: 4,5,6,7-Tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-2H-isoindolium diiodide

CAS Number: 96750-66-2
Empirical Formula (Hill Notation): C14H20Cl4I2N2
Molecular Weight: 611.94
MDL Number: MFCD01074794
Linear Formula: C14H20Cl4I2N2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C5366-10MG 10 mg
 $209.00
1/EA		 Add To Favorites
45-C5366-50MG 50 mg
 $787.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form solid
InChI 1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
InChI key FPNVAOZHQUJJJQ-UHFFFAOYSA-L
Quality Level 200 
SMILES string [I-].[I-].C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1
solubility DMSO: >20 mg/mL
  H2O: ≥2 mg/mL
storage condition protect from light
storage temp. 2-8°C
Application: Chlorisondamine diiodide has been used:
• as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
• as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
• as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress
Biochem/physiol Actions: Chlorisondamine diiodide mediates ganglionic and central blockade.
Biochem/physiol Actions: Irreversible, long-lasting nicotinic acetylcholine receptor antagonist.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Acetylcholine Receptors (Nicotinic)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352116

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