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8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt

SIGMA/C5438 - ≥95% (HPLC), powder

Synonym: 8-pCPT-cGMP; pCPT-cGMP

CAS Number: 51239-26-0
Empirical Formula (Hill Notation): C16H14ClN5NaO7PS
Molecular Weight: 509.79
MDL Number: MFCD00674888
Linear Formula: C16H14ClN5NaO7PS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C5438-10MG 10 mg
 $88.60
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45-C5438-50MG 50 mg
 $389.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C5438-50MG

 

assay ≥95% (HPLC)
color white
form powder
InChI 1S/C16H15ClN5O7PS.Na/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(28-14)5-27-30(25,26)29-11;/h1-4,8,10-11,14,23H,5H2,(H,25,26)(H3,18,20,21,24);/q;+1/p-1/t8-,10-,11-,14-;/m1./s1
InChI key REEQGIQRCDWDRA-ZBMQJGODSA-M
Quality Level 200 
SMILES string [Na+].NC1=Nc2c(nc(Sc3ccc(Cl)cc3)n2[C@@H]4O[C@@H]5COP([O-])(=O)O[C@H]5[C@H]4O)C(=O)N1
solubility H2O: 25 mg/mL
storage temp. −20°C
Application: 8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt has been used to activate GMP-dependent protein kinase (PKG) in vascular smooth muscle cells (VSMCs).
Biochem/physiol Actions: Membrane-permeable analog of cGMP that does not affect cGMP-regulated phosphodiesterase. A more potent cGMP analog than 8-Br-cGMP due to greater membrane permeability and a higher resistance to hydrolysis by phosphodiesterase. Used as a selective activator of cGMP dependent protein kinase (PKG). Found to be a very potent cyclic nucleotide-gated channel agonist.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the PKA & PKG  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10, 50 mg in poly bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 41106305

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