Complement factor D from human plasma
SIGMA/C5688 - 90-110 μg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)
CAS Number: 37213-56-2
MDL Number: MFCD00166417
Product Type: Chemical
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| assay | ≥90% (SDS-PAGE) |
| biological source | human plasma |
| concentration | 90-110 μg/mL in PBS, pH 7.2 |
| form | liquid |
| Quality Level | 200  |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | P00746  |
| Analysis Note: | Source plasma tested for HBSAg, HCV, HBC, syphillis, and HIV-1/HIV-2 |
| Application: | Complement factor D is a serine protease essential for the activation of the alternative pathway in the complement system. Research of complement factor D has revealed that a self inhibitory loop is responsible for switch from a resting to active state. Additionally, recent research has linked a complement factor D gene, single nucleotide polymorphism (SNP) rs3826945, with age-related macular degeneration (AMD). In these AMD cases there was a significant increase in plasma complement factor D concentration, even though previous research has shown no association between complement factor D SNP genes and AMD. |
| Biochem/physiol Actions: | Complement factor D is a serine protease with structural homologies with chymotrypsin. In the complement cascade, factor D cleaves complement factor B in complex with activated complement component C3. It is identical to adipsin, which is expressed in adipose tissue. |
| Disclaimer: | RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization. |
| Other Notes: | View more information on the complement pathway at www.sigma-aldrich.com/enz |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |