CGP 52608
SIGMA/C5749 - ≥98%, solid
Synonym: 1-
CAS Number: 87958-67-6
Empirical Formula (Hill Notation): C8H12N4OS2
Molecular Weight: 244.34
MDL Number: MFCD00942304
Linear Formula: C8H12N4OS2
Product Type: Chemical
| assay | ≥98% |
| form | solid |
| InChI | 1S/C8H12N4OS2/c1-3-4-12-6 |
| InChI key | DDYJDIHOSRTMSE-FLIBITNWSA |
| Quality Level | 100  |
| SMILES string | CNC(=S)NN=C1/SCC(=O)N1CC |
| solubility | DMSO: >30 mg/mL |
| H2O: insoluble | |
| storage temp. | −20°C |
| Application: | CGP 52608 has been used as a RAR related orphan receptor α (RORα) synthetic agonist in THP-1 macrophages, in human monocyte cells THP1 and somatic testicular cells. |
| Biochem/physiol Actions: | CGP 52608 is a specific activator of retinoic acid receptor-related orphan receptor α (RORA). |
| Biochem/physiol Actions: | CGP 52608 is a thiazolidine derivative and an antiarthritic compound. It possesses immunostimulatory functionality and elicits antiproliferative effect in colon tumors. It is cytotoxic towards neural cell lines. CGP 52608 induces apoptosis in tumor and also favors G0-G1 cell cycle phase accumulation in neural cell lines. |
| Features and Benefits: | This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |