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CGP 35348 hydrate

SIGMA/C5851 - ≥97% (NMR), solid

Synonym: (3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate

CAS Number: 123690-79-9 (free acid)
Empirical Formula (Hill Notation): C8H20NO4P · xH2O
Molecular Weight: 225.22 (anhydrous basis)
MDL Number: MFCD11045877
Linear Formula: C8H20NO4P · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C5851-5MG 5 mg
 $212.00
1/EA		 Add To Favorites
45-C5851-25MG 25 mg
 $720.00
1/EA		 Add To Favorites

 

assay ≥97% (NMR)
color white
form solid
InChI 1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2
InChI key SRBHGEXMDCJOMS-UHFFFAOYSA-N
originator Novartis
Quality Level 100 
SMILES string O.CCOC(OCC)P(O)(=O)CCCN
solubility H2O: >20 mg/mL
storage condition desiccated
storage temp. −20°C
Application: CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABAB) receptor inhibitor:
• to study its effects on intrinsic optical signal (IOS) in rat hippocampus
• alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
• to study its effects on hepatocellular carcinoma cells (HCC)
Biochem/physiol Actions: CGP 35348 is a γ-aminobutyric acid-B (GABAB) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier.
Disclaimer: Product is hygroscopic
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the GABAB Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (NMR)
Storage Temp. −20°C
UNSPSC 12352200

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