Cholesteryl hemisuccinate tris salt

SIGMA/C6013 - anionic detergent

Synonym: 3β-Hydroxy-5-cholestene 3-hemisuccinate; 5-Cholesten-3β-ol 3-hemisuccinate; CHEMS; CHS; Cholesteryl hydrogen succinate

CAS Number: 102601-49-0
Empirical Formula (Hill Notation): C₃₁H₅₀O₄ · C₄H₁₁NO₃
Molecular Weight: 607.86
MDL Number: MFCD00058298
Linear Formula: C₃₁H₅₀O₄ · C₄H₁₁NO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C6013-5G	5 g	$728.00 1/EAAdd To Favorites	Add To Favorites
45-C6013-25G	25 g	$2940.00 1/EAAdd To Favorites	Add To Favorites

assay	≥98% (TLC)
biological source	synthetic (organic)
form	powder
functional group	ester
InChI	1S/C31H50O4.C4H11NO3/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5;5-4(1-6,2-7)3-8/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33);6-8H,1-3,5H2/t21-,23+,24+,25-,26+,27+,30+,31-;/m1./s1
InChI key	SLDYONDUXRBLLR-XTCKSVDZSA-N
Quality Level	200
shipped in	ambient
SMILES string	NC(CO)(CO)CO.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCC(O)=O
storage temp.	−20°C

Application:	Cholesteryl hemisuccinate tris salt has been used: • to prepare solubilization buffer for glucan synthase assay • to prepare immunoprecipitation buffer for immobilization of opioid receptors on paramagnetic beads. • as a membrane stabilizer for liposomes and protein synaptogyrin-1 • as a component of a folate-modified self-microemulsifying drug delivery system. • with N-dodecyl β-D-maltoside (DDM) to solubilize erythrocyte ghosts and chemokine receptor CCR1 • for protein solubilization
Biochem/physiol Actions:	Cholesteryl hemisuccinate is an ionizable anionic detergent that stabilizes large unilamellar vesicles. These liposome vesicles act as delivery agents for anticancer drugs, oligonucleotides and antibiotics. Cholesteryl succinate also reportedly exhibits antiproliferative activity and may be clinically useful as antitumor agent.
Packaging:	5, 25 g in poly bottle
Preparation Note:	Cholesteryl hemisuccinate tris salt yields clear, colorless solution in methanol at 10 mg/ml.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (TLC)
Storage Temp.	−20°C
UNSPSC	12352211