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Cyproheptadine hydrochloride sesquihydrate

SIGMA/C6022 - ≥98% (TLC), solid

Synonym: Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride, hydrate (2:3)

CAS Number: 41354-29-4
Empirical Formula (Hill Notation): C21H21N·HCl·1.5H2O
Molecular Weight: 350.88
EC Number: 213-535-1
MDL Number: MFCD00012538
Linear Formula: C21H21N·HCl·1.5H2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C6022-100MG 100 mg
 $78.00
1/EA		 Add To Favorites
45-C6022-1G 1 g
 $283.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C6022-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C6022-1G

 

assay ≥98% (TLC)
color white to slightly yellow
form solid
InChI 1S/2C21H21N.2ClH.3H2O/c2*1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;;;;/h2*2-11H,12-15H2,1H3;2*1H;3*1H2
InChI key ZEAUHIZSRUAMQG-UHFFFAOYSA-N
originator Merck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level 200 
SMILES string Cl.CN1CCC(CC1)=C2/c3ccccc3C=Cc4ccccc24
solubility ethanol: soluble
  methanol: soluble
Application: Cyproheptadine hydrochloride sesquihydrate has been used in:
• testing anti-inflammatory activity in serotonin receptor (5-HT) induced inflammation
• the inhibition of 5-HT in in vivo and in vitro bioassays in crabs
• the inhibition of 5-HT in embryo physiological experiments

inhibition of calcitonin gene related peptide (CGRP)
Biochem/physiol Actions: Cyproheptadine hydrochloride sesquihydrate is a serotonin receptor (5-HT2/5-HT1C) antagonist, H1 histamine receptor antagonist and an antipruritic. The inhibition of 5-HT by cyproheptadine improves cognitive function in schizophrenia disorder. Cyproheptadine is effective for treating functional gastrointestinal disorders (FGIDs). Food and Drug Administration (FDA) approved cyproheptadine, has antidepressant and antiplatelet functionality. It may be effective in treating thromboembolic disorders. Cyproheptadine inhibits lysine methyltransferase 7/9 (Set7/9) leading to a decrease in estrogen receptor (ERα) expression and growth arrest in breast cancer cells.
Features and Benefits: This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S. . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 1 g in poly bottle
Packaging: 100 mg in poly bottle
Purity ≥98% (TLC)
UNSPSC 12352200

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