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Clindamycin 2-phosphate

SIGMA/C6427 - aminoglycoside antibiotic

Synonym: Clindamycin 2-dihydrogen phosphate

CAS Number: 24729-96-2
Empirical Formula (Hill Notation): C18H34ClN2O8PS
Molecular Weight: 504.96
EC Number: 246-433-0
MDL Number: MFCD07793328
Linear Formula: C18H34ClN2O8PS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C6427-50MG 50 mg
 $236.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: C6427-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: C6427-50MG

 

antibiotic activity spectrum Gram-positive bacteria
form solid
InChI 1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12?,13+,14-,15?,16+,18+/m0/s1
InChI key UFUVLHLTWXBHGZ-MWBQRTRKSA-N
mode of action protein synthesis | interferes
Quality Level 100 
SMILES string CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC([C@H](C)Cl)C2O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O
solubility DMSO: 224 mg/mL at 25 °C
storage temp. 2-8°C
Application: Clindamycin 2-phosphate is an aminoglycoside antibiotic that has been used to study the cytoxicity of antibiotics on human cell lines , Bacterial protein synthesis and peptide translation, and the inhibition of human Tyrosyl-DNA Phosphodiesterase .
Biochem/physiol Actions: Clindamycin 2-phosphate is a pharmacological tyrosyl-DNA phosphodiesterase (Tdp1) inhibitor. Clindamycin 2-phosphate can repair DNA topoisomerase I-DNA covalent complexes by hydrolyzing the tyrosyl-DNA bond. It inhibits protein synthesis in bacteria by binding the 50s ribosomal subunit. . Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Biochem/physiol Actions: Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.
General description: Chemical structure: macrolide
Other Notes: Antibacterial and antiprotozoal antibiotic of the licosamide class.
Other Notes: Keep container tightly closed in a dry and well-ventilated place.
Packaging: 50, 100 mg in poly bottle
Storage Temp. 2-8°C
UNSPSC 51102829

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