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Ciproxifan hydrochloride

SIGMA/C6492 - ≥98% (HPLC), solid

Synonym: Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxyl]phenyl]-methanone hydrochloride

CAS Number: 1049741-81-2
Empirical Formula (Hill Notation): C16H18N2O2 · HCl
Molecular Weight: 306.79
MDL Number: MFCD08705321
Linear Formula: C16H18N2O2 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C6492-5MG 5 mg
 $214.00
1/EA		 Add To Favorites
45-C6492-25MG 25 mg
 $579.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color off-white
form solid
InChI 1S/C16H18N2O2.ClH/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;/h5-8,10-12H,1-4,9H2,(H,17,18);1H
InChI key PWAPSKMHZQQTRJ-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.O=C(C1CC1)c2ccc(OCCCc3c[nH]cn3)cc2
solubility DMSO: 30 mg/mL
  water, high purity: 30 mg/mL
storage condition desiccated
  under inert gas
storage temp. 2-8°C
Biochem/physiol Actions: Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.
Biochem/physiol Actions: H3 histamine receptor antagonist.
Features and Benefits: This compound is featured on the Histamine Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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