4-Chloro-DL-phenylalanine
SIGMA/C6506
Synonym: PCP; PCPA
CAS Number: 7424-00-2
Empirical Formula (Hill Notation): C9H10ClNO2
Molecular Weight: 199.63
EC Number: 231-051-9
MDL Number: MFCD00002601
Linear Formula: ClC6H4CH2CH(NH2)CO2H
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C6506-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C6506-5G
12 Principles of Green Chemistry: Principle 3—Less Hazardous Chemical Syntheses. This product manufacturing process was designed with lesser toxicity to human health and the environment.
12 Principles of Green Chemistry: Principle 4—Designing Safer Chemicals
Chemical products should be designed to affect their desired function while minimizing their toxicity.
Chemical products should be designed to affect their desired function while minimizing their toxicity.
| form | solid |
| greener alternative category |  , Re-engineered |
| greener alternative product characteristics | Less Hazardous Chemical Syntheses Designing Safer Chemicals Design for Energy Efficiency Learn more about the Principles of Green Chemistry . |
| greener alternative product score | old score: 2 new score: 1 Find out more about DOZN™ Scoring |
| InChI | 1S/C9H10ClNO2/c10-7-3-1-6 |
| InChI key | NIGWMJHCCYYCSF-UHFFFAOYSA |
| mp | >240 °C (dec.) (lit.) |
| Quality Level | 100 |
| SMILES string | NC(Cc1ccc(Cl)cc1)C(O)=O |
| storage temp. | room temp |
| sustainability | Greener Alternative Product |
| Application: | 4-Chloro-DL-phenylalanine has been used: • as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish • to induce insomnia in rat models • used to treat embryos to examine its effect on serotonin • for the selection of Enterococcus faecalis transformants with pESentA32 plasmid • to feed flies to explore serotonin effect |
| Biochem/physiol Actions: | 4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors. |
| Biochem/physiol Actions: | Tryptophan hydroxylase inhibitor. |
| General description: | We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard. |
| Packaging: | 5, 25 g in poly bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 - H317 |
| Precautionary statements | P280 - P301 + P310 + P330 - P302 + P352 |
| Hazard Codes | T |
| Risk Statements | 25-43 |
| Safety Statements | 36/37-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | >240 °C (dec.) (lit.) |
| Storage Temp. | room temp |
| UNSPSC | 12352209 |