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CBIQ

SIGMA/C6617 - ≥98% (HPLC), solid

Synonym: 4-Chlorobenzo[f]isoquinoline

CAS Number: 32081-28-0
Empirical Formula (Hill Notation): C13H8NCl
Molecular Weight: 213.66
MDL Number: MFCD02179769
Linear Formula: C13H8NCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C6617-5MG 5 mg
 $180.00
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45-C6617-25MG 25 mg
 $711.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color off-white
form solid
InChI 1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H
InChI key SHQLTRRYZVBEMR-UHFFFAOYSA-N
Quality Level 100 
SMILES string Clc1nccc2c1ccc3ccccc23
solubility DMSO: 15 mg/mL
Biochem/physiol Actions: CBIQ is a cystic fibrosis transmembrane conductance regulator (CFTR) activator; intermediate-conductance calcium-sensitive K+ channel (KCNN4) activator.
Biochem/physiol Actions: CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.
Features and Benefits: This compound is featured on the Chloride Channels  and Potassium Channels  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
UNSPSC 12352200

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