Advanced Search



Clofibrate

SIGMA/C6643 - liquid

Synonym: 2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester; Ethyl 2-(4-chlorophenoxy)-2-methylpropionate; Ethyl 2-(4-chlorophenoxy)isobutyrate

CAS Number: 637-07-0
Empirical Formula (Hill Notation): C12H15ClO3
Molecular Weight: 242.70
EC Number: 211-277-4
MDL Number: MFCD00000615
Linear Formula: C12H15ClO3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C6643-250MG 250 mg
 $66.40
1/EA		 Add To Favorites
45-C6643-1G 1 g
 $71.60
1/EA		 Add To Favorites
45-C6643-5G 5 g
 $297.00
1/EA		 Add To Favorites
45-C6643-10G 10 g
 $537.00
1/EA		 Add To Favorites

 

color clear colorless
density 1.14 g/mL at 25 °C (lit.)
form liquid
InChI 1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChI key KNHUKKLJHYUCFP-UHFFFAOYSA-N
originator Wyeth
Quality Level 200 
SMILES string CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
storage temp. 2-8°C
Application: Clofibrate has been used:
• as a quinolinate phosphoribosyltransferase (QPRT) agonist to study its effects on hepatitis C virus (HCV) infection
• as peroxisome proliferated activated receptor (PPAR) agonist to study its effects on autophagy in rat liver cells
• as a hepatotoxicant to study its effects on gene expression in primary rat hepatocytes
Biochem/physiol Actions: Clofibrate is a peroxisome proliferated activated receptor α (PPARα) agonist. It is a fibric acid derivative and has a therapeutic effect on hypertriglyceridemia and hyperlipoproteinemia type III. Clofibrate participates in lowering the very-low-density lipoprotein (VLDL) and cholesterol levels in hyperlipoproteinemia type III patients. It facilitates the decrease of total serum bilirubin concentration in Gilbert′s syndrome.
Features and Benefits: This compound is featured on the Nuclear Receptors (PPARs)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Wyeth . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 1, 5, 10 g in glass bottle
Packaging: 250 mg in glass bottle
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
Density 1.14 g/mL at 25 °C (lit.)
Storage Temp. 2-8°C
UNSPSC 12352200

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Tariffs & Effects on Pricing

Tariff note: As we navigate the current environment of tariff surcharges and mid-year manufacturer price increases, we want to keep you informed. While we have avoided making specific decisions thus far, we anticipate that we will be forced to implement a cost adjustment policy to offset the fees we have already been absorbing. We are committed to transparency and moderation in this process.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top