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Z-Leu-Leu-Norvalinal

SIGMA/C6706 - ≥90% (HPLC), powder

Synonym: MG115; Z-LLnV

CAS Number: 133407-86-0
Empirical Formula (Hill Notation): C25H39N3O5
Molecular Weight: 461.59
MDL Number: MFCD00274411
Linear Formula: C25H39N3O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C6706-5MG 5 mg
 $305.00
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assay ≥90% (HPLC)
color white
form powder
InChI 1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
InChI key QEJRGURBLQWEOU-FKBYEOEOSA-N
Quality Level 100 
SMILES string CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
solubility DMSO: soluble
storage temp. −20°C
Amino Acid Sequence: Z-Leu-Leu-Nva
Biochem/physiol Actions: Potent inhibitor of the 20S proteasome (Ki = 21 nM) and 26S proteasome (Ki = 35 nM). Cells treated with 54 μM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.
Packaging: 1, 5 mg in serum bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥90% (HPLC)
Storage Temp. −20°C
UNSPSC 12352209

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